- Itraconazole is used to treat a variety of fungal infections. It belongs to a class of drugs known as azole antifungals. It works by stopping the growth of fungi. One capsule contains 100 mg itraconazole.
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Therapeutic indications
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Itraconazole is indicated for the treatment of the following fungal infections when thought likely to be susceptible:
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Vulvovaginal candidiasis.
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Pityriasis versicolor.
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Dermatophytoses caused by organisms susceptible to itraconazole (Trichophyton spp. Microsporum spp. Epidermophyton floccosum) e.g. tinea pedis, tinea cruris, tinea corporis, tinea manuum.
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Oral candidiasis.
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Onychomycosis caused by dermatophytes and/or yeasts.
- How to use
- Method of administration: Itraconazole is for oral administration and must be taken immediately after a meal for maximal absorption.
Indication
Dose:
- Vulvovaginal candidiasis-200 mg twice daily for 1 day.
- Pityriasis versicolor-200 mg once daily for 7 days.
- Tinea corporis, tinea cruris-100 mg once daily for 15 days.
- Tinea pedis, tinea manuum-100 mg once daily for 30 days.
- Oral candidiasis-100 mg once daily for 14 days.
- Onychomycosis-200 mg once daily for 3 months.
Precautions
Contraindications: Itraconazole is contraindicated in patients with known hypersensitivity to the active substance or to any of the excipients listed. Co-administration of the following substances is contraindicated with Itraconazole:
- Substrates metabolized via cytochrome P450 3A4, that can prolong the QT interval, such as astemizole, bepridil, cisapride, dofetilide, levacetylmethadole (levomethadyl), mizolastine, pimozide, quinidine, sertindole and terfenadine. - Co-administration may result in increased plasma concentrations of these substrates, which can lead to QT prolongation and rare occurrences of torsade de pointes.
- HMG-CoA reductase inhibitors metabolized via cytochrome P450 3A4 such as atorvastatin, lovastatin and simvastatin
- Triazolam and oral midazolam.
