Daboral® contains Aminosidine Sulphate (paromomycin) which is an aminoglycoside antibiotic. Aminosidine has a broad spectrum of activity, including activity against protozoa especially Entamoeba histolytica, bacteria and cestodes. The drug is believed to act against both the trophozoite and encysted forms of Entamoeba. Aminosidine has an antibacterial spectrum similar to that of neomycin. Aminosidine is active against some gram-positive bacteria (e.g. some strains of Staphylococcus) and many gram-negative aerobic bacteria, but generally is inactive against Pseudomonas aeruginosa and anaerobic bacteria. Aminosidine also has some activity against Mycobacterium tuberculosis.
Dose
Amoebiasis, Giardiasis (Lambliasis) and Balantidiasis: Adults: 500 mg twice a day for 5-7 days. Children: 30 mg/kg/day in two divided doses for 5-7 days.
Precautions
The use of Aminosidine may result in the overgrowth of non-susceptible organisms, especially Candida, and patients should be carefully monitored for the development of new infections caused by nonsusceptible organisms. Secondary Staphylococcus enterocolitis may occur. Aminosidine should be administered with caution to patients with ulcerative intestinal lesions to avoid renal toxicity through inadvertent absorption of the drug.
