Intamine Cream contains mepyramine maleate which is an antihistamine. Mepyramine works by preventing the actions of histamine- a compound produced by the body when it reacts to a foreign substance, such as venom from insect bites or stings (these are known as allergens).DoseApply the cream to the affected area of skin two or three times a day for up to three days.PrecautionDo not apply the cream to raw, broken, cut or grazed areas of skin, or skin that is sunburnt or affected by eczema. Do not use the cream if you're allergic to any of its ingredient.