Unibrol 125 mg/5ml contains Aminosidine (paromomycin) which is an aminoglycoside antibiotic that has been administered by mouth as sulphate in the treatment of intestinal protozoal infection including amoebiasis, cryptosporidiosis, and giardiasis. It has also been tried parenterally for visceral and topically for cutaneous leishmaniasis. Aminosidine may also be used for the treatment of tapeworm infection, but it is not the treatment of choice. It is active against many strains of gram-negative bacteria including species of Brucella, Calymmatobacterium, Campylobacter, Citrobacter, Escherichia, Enterobacter, Klebsiella, proteus, Serratia Vibrio and Yersinia. Aminosidine has been reported to be active against Mycobacterium tuberculosis but lacks activity against Pseudomonas aeruginosa.
How to use
For Amoebiasis, Lambliasis, cryptosporidiosis and trichomoniasis: Adult- 500 mg twice per day for 6 days.
Children: 15 mg/kg/day for 6 days.
For prophylactic sterilization in gastrointestinal Surgery: Adult- 2 gm daily for 3 days.
Children 50 mg/kg/day for 3days.
In taeniasis and other tapeworm infections: a dose of 4 gm is given by mouth as a single dose or in divided doses over the course of one hour. For hepatic encephalopathy: 4 gm is given daily by mouth in divided doses at regular intervals for 5 to 6 days.
Precautions
Aminosidine is contraindicated for intestinal disinfection when an obstruction is present and in patients with a known history of allergy to aminoglycosides. It should be used with great care in patients with kidney or liver disease or neuromuscular disorders and those with impaired hearing.
